Lactic acid levels are often elevated because of hypoperfusion and the altered balance of reduction and oxidation reactions in the liver. Symptoms result not only from an anion gap metabolic acidosis but also from coexisting disorders, like withdrawal from alcohol and the acute effects of binge drinking. Laboratory testing reflects the combination of these disorders. Increased availability of free fatty acids, which provide the major substrate for ketone body formation.

what is alcoholic ketoacidosis

Mortality specifically due to AKA has been linked to the severity of serum beta-hydroxybutyric acid in some studies. The etiology of Alcoholic ketoacidosis stems from the patient’s inability to ingest, absorb and utilize glucose from their diet. The vomiting and nausea prevent adequate solute intake from the gastrointestinal tract. The alcohol further depresses gluconeogenesis in the body and keeps blood sugar levels low.


If you need help talking to a loved one, look into family resources for alcohol addiction treatment. Excessive drinking damages the pancreas, impacting insulin production. When this happens, your cells will have to burn fat to produce energy.

Symptoms often include abdominal pain, vomiting, agitation, a fast respiratory rate, and a specific «fruity» smell. AKA has to be in the differential diagnosis of an elderly patient presenting to the hospital with altered mental status and metabolic acidosis. Although not very well known, high osmolal gap is an important characteristic alcoholic ketoacidosis of AKA and is attributed mainly to acetone, glycerol, and acetone metabolites such as acetol and 1,2-propanediol. Because of the high osmolal gap in AKA, it is difficult at times to exclude the simultaneous presence of toxic alcohol. An elevated anion gap metabolic acidosis and ketosis is the classic present.


These neurotransmitters are responsible for mood regulation and other important processes in the brain. When they are disrupted by alcohol dependence, it can lead to serious mental health issues such as depression and anxiety disorders. The most well-known effect of alcohol addiction is its impact on the brain.

Mildly elevated osmolal gaps can exist, but it is important to consider co-ingestions, or other causes of anion gap acidosis, if the gap fails to close with ongoing fluid and carbohydrate treatment. Hypophosphatemia is common in alcoholics and can retard the resolution of acidosis because phosphorus is necessary for mitochondrial utilization of glucose for oxidation of NADH. Alcoholic ketoacidosis is a condition that presents with a significant metabolic acidosis in patients with a history of alcohol excess.

Lisinopril & Alcohol – Is it Safe? | Transcend Recovery Community

This buildup of ketones can produce a life-threatening condition known as ketoacidosis. 13.Iten PX, Meier M. Beta-hydroxybutyric acid–an indicator for an alcoholic ketoacidosis as cause of death in deceased alcohol abusers. Summarize the importance of collaboration and communication among the interprofessional team to enhance the delivery of care for patients affected by alcoholic ketoacidosis. Once a person has AKA, it is critical to seek emergency treatment for symptoms right away. Doctors can administer sugars and salts intravenously to counteract the effects of AKA, and monitor the blood composition and ketone levels of the patient.

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *